2023 in science - Wikipedia Schmitt, T. Molecular biogeography of Europe: Pleistocene cycles and postglacial trends. For the placement of individuals onto a Y-chromosomal phylogenetic tree (Extended Data Fig. Sign up below if you'd like to join a growing community that is enthusiastic about learning and improving their lives. T.T., D.C. and E.A. Genomic insights into the origin of farming in the ancient Near East. and J.Krause performed or supervised genetic analyses. ScienceDaily. ScienceDaily. To bind DNA, silica columns for high volumes (High Pure Viral Nucleic Acid Large Volume Kit (Roche)) were used. Nature 551, 368372 (2017). Wren, C. D. & Burke, A. Habitat suitability and the genetic structure of human populations during the Last Glacial Maximum (LGM) in Western Europe. Us Too. In other cases, you may have to create a more complex database structure (such as SQLite). Between 14 and 8ka, all hunter-gatherers in western and central Europe carried only Oberkassel ancestry, with no detectable contribution from the Sidelkino cluster. 1c). PubMedGoogle Scholar. "Unlike diving into the university life directly, the pathways program is a buffer that allows international students to be better prepared. 27 and 28). Dismiss. The PCA was calculated with 1379 individuals from 87 western Eurasian modern populations on the 1240k_HO dataset, which was intersected between the 1240k and Human Origins datasets (Supplementary Data 1.K). Proc. Its also hard to predict whats going to happen, but I hope its interesting to people who want to learn more about data science. Tina Huang is a well-known data scientist who has over 10 years of experience on YouTube and has previously worked at a FAANG organization. Evol. Archeol. Materials provided by Max Planck Institute for Evolutionary Anthropology. The de-multiplexed capture sequencing reads were cleaned and mapped to human reference genome hs37d5 using EAGER pipeline 1.92.5564. Ideally, we also want lots of data because this will give us more confidence in our results. Check out Do Deepfakes Have Fingerprints? Patterson, N. et al. PubMed Central Amina is a software engineer, who is also an accessibility advocate and content creator. Disease-modifying, readily available, and easily affordable medical therapies for hypertension are ubiquitous and set a high bar for any new therapeutic. In the MDS plot, we find that all of the newly and previously reported Epigravettian-associated individuals fall within the Villabruna cluster4 (Fig. I have an undergraduate degree in . The newly reported individuals with over 15,000 SNPs on the Human Origins dataset are shown in black-outlined and filled symbols, as illustrated in the legend on the right, while representative ancient genomes are shown in outlined symbols, as illustrated in the legend at the bottom of the PCA. The x-axis shows the average age of each tested individual/group and the y-axis shows the proportion of Sidelkino ancestry, relative to the total hunter-gatherer ancestry (Oberkassel + Sidelkino) in each group. The f3-statistics were calculated with qp3Pop 435 in ADMIXTOOLS 5.1 package103. Charlton, S. et al. Pseudo-haploid genotypes were called on the targeted SNPs by randomly sampling a single allele at each position, resulting in individuals with 6,600 to 1.07 million SNPs covered on the 1.24-million-SNP panel (Extended Data Table 1 and Supplementary Data 1.A). Dr. Huang received her BS degree in Chemistry from Bethel College and her PhD in Analytical Chemistry from the University of Kansas in 1998. Cardiff University / Prifysgol Caerdydd. Evol. Protoc. J. Archaeol. Questions? Modern humans have populated Europe for more than 45,000 years1,2. Nature 528, 499503 (2015). Tina is a computer science student at Stanford University. Rev. Jones, E. R. et al. Photo by Sara Kurfe on Unsplash 1. This plot reveals the presence of three distinct groupings: (1) a pre-40ka group with individuals from the UstIshim, Bacho Kiro, Zlat k and Petera cu Oase sites, (2) a Vstonice cluster including Gravettian-associated individuals from centraleastern and southern European sites (Doln Vstonice, Pavlov, Krems-Wachtberg, Paglicci and Ostuni), and (3) a Fournol cluster(hereafter, Fournol cluster or ancestry) comprising Gravettian-associated individuals from western and southwestern European sites (Ormesson, La Rochette, Fournol and two Seriny cave sites (Mollet III and Reclau Viver)). Tina Huang is very empowering, and she knows what she is talking about. 5). Soonafter8 ka, Sidelkino ancestry was absent in eastern Spain but it had already reached northern Iberia alongside an increase in Oberkassel ancestry (Fig. Trzej niedwiedzi braciszkowie przeywaj swoje dziecistwo, pakujc si w najrozmaitsze tarapaty za spraw magicznego pudeka. 12, 5425 (2021). Taipei, Taiwan . C.L.S. Folding bicycle. Created by DataSciencePR. CAS As recommended, we analysed individuals with over 400,000 SNPs called on the 1240k panel101 and we called ROH longer than 4cM (Supplementary Data 3.B). Newsletter, Twelve-month follow-up after hospitalization for SARS-COV-2: physiology These results show that some, but not all, of the genomic ancestries present in Europe between around 40ka and 30ka survived in the Gravettian-associated populations studied so far. This course is the perfect balance of teaching technical SQL concepts and optimal approaches to solving coding questions on interviews. Conversely, individuals in the Sidelkino cluster are genetically closer to AG3 than Tutkaul 1. Raghavan, M. et al. This is also supported by f4-statistics of the form f4(Mbuti, Fournol 85; Sunghir, test), which are significantly positive for all the individuals included in the Vstonice cluster (Supplementary Data 2.B). In addition, our phylogeographic analysis points to northeastern Italy as the possible entry point of the Epigravettian-associated gene pool in the Italian peninsula. While terms such as lithic industry, techno-complex, prehistoric tradition, and so on might be more appropriate to refer to the various associated chrono-cultural subdivisions, they concern different levels of discussion and are not applicable to all contexts investigated here. Biol. Along with pushing for more accessibility, she also creates content around working in the tech industry, the challenges that come with it, and career advice. Other individuals from that period, such as Zlat k from Czechia and UstIshim from Russia, do not carry significantly more Neanderthal ancestry than other non-African groups1,7, indicating differential interactions between Neanderthals and early modern humans during their initial expansions across Eurasia. These f4-statistics also confirm that Goyet Q376-3 carries a similar ancestry to Goyet Q116-1 and Kostenki 12 carries a similar ancestry to the Sunghir group, whereas Bacho Kiro 1653 (35ka) from Bulgaria, Muierii 1 (34ka) and Cioclovina 1 (32ka) from Romania, and Paglicci 133 (33ka) from southern Italy are equally related to Goyet Q116-1 and Sunghir. Oxidation of methane into valuable chemicals, such as C 2+ molecules, has been long sought after but the dilemma between high yield and high selectivity of desired products remains. It is generated automatically, and you can download, view, and share it at any time. 39, msac017 (2022). Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness and poor molecular preservation of human remains from that period3. Purchasing this course makes it your own. Extended Data Fig. For ds_halfUDG libraries, we called genotypes on all targeted sites from 2bp-masked bam files; for ds_nonUDG libraries, we called genotypes on transversion sites only; for ss_nonUDG libraries, we called genotypes with single-strand mode, which ignores forward reads at C/T polymorphisms and reverse reads at G/A polymorphisms. Google Scholar. Then pseudo-haploid genotypes were called using pileupCaller 1.4.0.2 (https://github.com/stschiff/sequenceTools) under random haploid calling mode. We give some of our best tips to improve them and hopefully help you all land a data science interview. It just raised $12.2 million. The expansion of farming by9,8, 7.5 and7 kais shown as green shades. Genetically, however, the populations from western and southwestern Europe (today's France and Iberia) differed from contemporaneous populations from central and southern Europe (today's Czech Republic and Italy). H. Rougier, I.C., L.K.,A. Morala, M. Ru, S.M., L.C., J.-B.C., E. Bocaege, S. Ricci, F.B., P. Bayle, B.M., F.L.B.-R., J.-G.B., G.O., E. Bortolini, O.B.-L., G.D., M.O., A.Z., V.S., E.S., L. Sineo, J.v.d.P., L. Pecqueur, G.M., G.G., J.-M.L., C.B.G., A.G.-O., M.P.-B., D.B., M.L.L., P. Storm, C.H., J. Kabaciski, T. Filimonova, S.Shnaider, N.B., B.G.-R., M.R.G.M., A.B.M.-A., B.L., C.A.-L., A.R., C. Polet, I.J., N. Cauwe, J.Soler, N. Coromina, I.R., R.C., G. Clark, L.G.S., M.-A.J., S. Rehart, D.T., S.B., M. Romandini, L.A., H. Bocherens, C.W., S. Villotte, J.F.-L.d.P., M.G.-P., M.A.E.-B., P. Bodu, L. Smits, B.S., R.J., J. Kozakait, C.C., H. Benthien, K.W., R.W.S., S.C.F., T. Schler, C.T., D.G., F.L., A. Kotula, H.P., F.S., J.Svoboda, S.Szelov,A.C., A. Khokhlov, N.J.C., F.V., K.H., P. Semal, B.J., A. Suvorov, R. Schulting, V.M., K.M., A.B. This suggests that genetic links between southern and southwestern European hunter-gatherers around the time of the LGM extended north of the Pyrenees. A genome sequence from a modern human skull over 45,000 years old from Zlat k in Czechia. Article Upper Palaeolithic genomes reveal deep roots of modern Eurasians. PubMed Central 9 posts. She graduated with a degree in Computer Science and Applied Math. The average calibrated date is shown, with pie charts indicating the estimated proportion of ancestry for each group or individual. . 1 and 2). Former Apple and Twitter Engineer Explains Why She Started - Insider Get the latest science news in your RSS reader with ScienceDaily's hourly updated newsfeeds, covering hundreds of topics: Keep up to date with the latest news from ScienceDaily via social networks: Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. eLife 11, e77625 (2022). We report 47 new radiocarbon dates performed on skeletal elements of 40 individuals by the Curt-Engelhorn-Zentrum Archaeometrie in Mannheim (MAMS, n=29), Center for Isotope Research, University of Groningen (GrA and GrM, n=5), University of Aarhus (AAR, n=3), Beta Analytics (Beta, n=2), Zrich (ETH, n=3), International Chemical Analysis (ICA, n=2), Natural History Museum in Paris (Echo Lab, n=1) and Vilnius (FTMC, n=2) (Supplementary Data 1.A). Data Professor - How to Become a Data Scientist at FAANG - Facebook Instead, in southern Europe, a distinct hunter-gatherer genetic profile was found as early as 17ka in individuals associated with the Epigravettian culture15 (2412ka, from the Italian peninsula to the southeastern European Plain across the Balkans). In addition to this general data science content, Tina teaches SQL . Note: Content may be edited for style and length. USA 111, 22292234 (2014). Wood, R. E. et al. The increasing level of admixture between distinct hunter-gatherer populations from around 8ka onwards indicates an intensified mobility of those forager groups. Paradis, E., Claude, J. How to Become a Data Scientist at FAANG (Ft. Tina Huang) In this video, I had the opportunity to talk with Tina Huang, a Data Scientist at one of the FAANG companies. This genetic signature is shared among individuals associated with the archaeologically defined Gravettian culture (3326ka) in central and southern Europe and seemingly disappeared after the Last Glacial Maximum4 (LGM). PubMed Central Instagram has an infinite scroll, and Uber has different options such as UberXL and Uber Pool. Basically, you minimize effort and maximize outcomes. Were dedicated to providing you the best ofNews, with a focus on dependability andBusiness. Los Angeles, California, United States. But she came up with a way to break down the code and create a website that she was proud of. van de Loosdrecht, M. et al. About the author: Tina Huang is a data scientist at one of the FAANG companies. Sci. Tina Huang is a statistician who focuses on the statistical modeling and analysis of big data. Tina Huang, born on October 28, 1981, is an American stage and television actress of Taiwanese descent known for her recurring roles in Rizzoli & Isles and for her semi-regular role as Melinda Trask on the NBC soap Days of Our Lives. EY. C. Posth, H.Y., A.G., A.B.R., W.H. Check out Bootcamps Yes or nah? K.N., V.V.-M., R.R., T. Ferraz, R.T., D.G.D., M.L., A. Modi, S. Vai, T. Saupe, C.L.S., G. Catalano, L. Pagani, D.C. and E.A. Hunter-gatherers across the great Adriatic-Po region during the Last Glacial Maximum: environmental and cultural dynamics. Google Scholar. Sci. Each bar represents one individual with the ROH grouped in four length categories (grouped by colour). BMC Res. Populations headed south? Thats exactly why choosing the right feature to build is so important! We looked at data on how many people had been dropped, the time when they were dropped, and the time they were found. Genomic structure in Europeans dating back at least 36,200 years. Conversely,additional Oberkassel ancestry is identified in eastern Europe by at least 7.5ka in newly generated genomes from Minino I and Yazykovo from the upper Volga region, whereasa 1,000-years-older individual from Minino I did not have this genetic component. Greater San Diego Area. 3). Its no surprise that she was selected for the Code Cup, a yearly event where students from all over the world compete in coding challenges. The Italian peninsula was previously considered to be another climatic refugium for humans during the LGM. 9) and testing the relative affinity among them using f4-statistics in the form f4(Mbuti, Epigravettian A; Epigravettian B, Epigravettian C) (Supplementary Data 2.E). https://doi.org/10.1038/s41586-023-05726-0, DOI: https://doi.org/10.1038/s41586-023-05726-0. Nature 570, 182188 (2019). For phylogenetic reconstruction (Extended Data Fig. Sydney, Australia. Tina Huang, a former engineer at Apple, Google, and Twitter, explains why she started API management startup Transposit. Edit your profile. 27, 21852193.e6 (2017). Pleistocene North African genomes link Near Eastern and sub-Saharan African human populations. Tina Huangis a data scientist currently working at a large FAANG enterprise. Reducing microbial and human contamination in DNA extractions from ancient bones and teeth. 365 Data Use Cases: Data Science and Product Development with Tina Huang A user manual including an installation guide is available at https://haproh.readthedocs.io/en/latest/hapROH_with_contamination.html. Tina Huang (@hellotinah) Instagram photos and videos All enrolled students have access to course exams no matter how many lessons they have watched in a course. First up is the MIT researcher and YouTuber Jordan Harrod. The data here can also be structured or unstructured. 116, 105100 (2020). has received funding from the Van de Kamp fonds. This suggests that the newly reported Neolithic individual from central Asia carries an ancestry that might be a good proxy for the ANE-related contribution to Iran and the Turan region45 from around 5.5ka but not to roughly contemporaneous hunter-gatherers from eastern Europe. Develped strategies for promoting G-Mark to Taiwan. This derived ancestrythe Fournol clustersurvived during the LGM in Solutrean-associated individuals, possibly within the Franco-Cantabrian climatic refugium25, leading to later populations associated with the Magdalenian culture (GoyetQ2 cluster and El Mirn). CAS mtDNA capture63 was also performed for those libraries where mtDNA coverage was not high enough to assess mtDNA haplogroup and contamination. Gonzlez-Fortes, G. et al. In her journey of eventually becoming a data scientist, Tina started out with an undergraduate in Pharmacology. Google Scholar. Overall, the literature suggests that Chinese Canadian students demonstrate high levels of achievement and that this academic success is associated with factors such as stronger feelings of ethnic identity, better English language skills in the family, Chinese . 4. Svensson, E. et al. 803147-RESOLUTION (to S.T. Nakatsuka, N. et al. You can also check out our video on the topic below or scroll down to keep on reading. This means that you have to set up the database tables to represent the data (which can be done by using the right database design patterns) and then run some SQL queries to extract the data that you need. The genomic similarity of the Oberkassel cluster to Arene Candide 16 in northwestern Italy might imply that Epigravettian-associated ancestry spread from the south to central Europe passing through the western side of the Alpine region. 5 and Supplementary Information, section9). Key, F. M. et al. The nucleolus is the largest substructure in the nucleus, where ribosome biogenesis occurs. Consultant - October 2015 to June 2016. PubMed 14), most post-14ka individuals from western and central Europe fall close to the WHG cluster and those from eastern Europe close to the EHG cluster, whereas the Tutkaul 1 individual from central Asia falls close to the ANE-related group. You need more data until you have the right ingredients to make a good recipe, but you also need less data until you have the right amount of ingredients to make a bad recipe. My main tasks: Modeling and developing the data structures and processes to optimize the loads of information, discovering insights and creating and maintaining reports. Designed for aspiring data scientists, data analysts, and BI analysts, this course is the perfect resource for anyone who needs a winning strategy to pass the SQL interview and land their dream job. 1c and Extended Data Fig. Rep. 10, 21931 (2020). What is Kagi Chart in Data Visualization? Biol. Then the cleaned reads together with cleaned reads from 1240k capture sequencing were mapped to human reference mitochondrial sequence NC_012920.1 with BWA 0.7.12 aln/samse algorithm (parameters n 0.01, l 16500) and realigned with CircularMapper64. Originally published at https://365datascience.com on October 1, 2020. A software engineer who now works as a content creator full-time, Mayuko Inoue runs a YouTube channel dedicated to software engineering, working in the tech industry, and life in general. Tina Huang | Continuing Studies at UVic
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